Wednesday, May 13, 2020

Systematic Review Paper - 981 Words

ABSTRACT Introduction: Advances in early detection and treatment of colorectal cancer has seen marked improvements in recent years. However, it is still the third leading cause of cancer related death worldwide. Although there are studies reporting the significance of miRNAs in stage II colorectal cancer, there is, as of yet, no known comprehensive study utilizing collective data from multiple published studies. It is imperative that this knowledge gap of viable miRNA biomarkers in stage II colorectal cancer, be filled. Thus, this study will focus on performing a systematic review and meta-analysis using collective data to identify and underline multiple miRNA targets, with regards to disease prognosis in stage II colorectal cancer†¦show more content†¦Review registration number: Strengths and limitations of this study †¢ The protocol follows the PRISMA-P guidelines. †¢ This is the first study of its kind, with a comprehensive analysis of the prognostic effects of miRNA in stage II colorectal cancer in the form of a systematic review and meta-analysis. †¢ Reporting bias may occur due to the exclusion of articles published in languages other than English, articles published prior to 2009 and unpublished articles. This is to ensure that the results of this study are specific, currently relevant and accurately replicable. INTRODUCTION Colorectal Cancer (CRC), also known as colon cancer or bowel cancer, is cancer originating from colon or rectal lining, where healthy cells transform into cancerous cells, leading to formation of large, rapidly growing tumours which remain benign or become malignant as the disease progresses. The Australian government’s (Cancer Australia) 2017 estimate suggests 16,682 (12.4%) new cases out of which 4,114 (8.6%) cases were reported as leading to death.1 Similarly, the American cancer society estimated 95,520 new cases of colon cancer and 39,910 cases of rectal cancer diagnosed in the United States of America (USA) in 2017.2 CRC is staged according to the extent of primary organ tumour development and metastatic spread to lymph nodes or distant organs due to their malignancy. Although surgical resection can be highly effective for localized disease, 25%-40% of patientsShow MoreRelatedSystematic review paper1119 Words   |  5 Pagesï » ¿ Systematic Review Systematic Review The purpose of this meta-synthesis research was to synthesize a qualitative study performed to better understand the underlying reasons why only a fraction of cancer patients participate in cancer research trials. The attempt is to explore factors that influence participation in this type of study. Literature in the subject indicates poorly understood process of how patients are enrolled into clinical trials. This systematic review tries to improveRead MoreA Comprehensive Treatment Plan Based Off Diagnosis Of The Problems At Hand904 Words   |  4 Pages(SRP), prophylaxis, root canal therapy (RCT), post and core, porcelain fused metal crown, and night guard were the major treatments. While broken teeth and possible caries lesions will be watched to see if further intervention needed. 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